3EPZ

Structure of the replication foci-targeting sequence of human DNA cytosine methyltransferase DNMT1

3EPZ の概要

• エントリーDOI: 10.2210/pdb3epz/pdb
• 分子名称: DNA (cytosine-5)-methyltransferase 1, ZINC ION, beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: winged helix domain, sh3-like barrel, cell cycle, metal binding, dna binding, dna replication, transcriptional silencing, chromatin, phosphorylation, transcription, transcription regulation, transferase, epigenetics zinc, zinc-finger, methyltransferase, nucleus, phosphoprotein, repressor, s-adenosyl-l-methionine, structural genomics, structural genomics consortium, sgc
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 61256.43

構造登録者

Walker, J.R.,Avvakumov, G.V.,Xue, S.,Li, Y.,Bountra, C.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bochkarev, A.,Dhe-Paganon, S.,Structural Genomics Consortium (SGC) (登録日: 2008-09-30, 公開日: 2008-11-25, 最終更新日: 2020-07-29)

• 主引用文献: Syeda, F.,Fagan, R.L.,Wean, M.,Avvakumov, G.V.,Walker, J.R.,Xue, S.,Dhe-Paganon, S.,Brenner, C.; The replication focus targeting sequence (RFTS) domain is a DNA-competitive inhibitor of Dnmt1.; J.Biol.Chem., 286:15344-15351, 2011; PubMed: 21389349; DOI: 10.1074/jbc.M110.209882

実験手法

X-RAY DIFFRACTION (2.31 Å)