3EOC

Cdk2/CyclinA complexed with a imidazo triazin-2-amine

3EOC の概要

分子名称Cell division protein kinase 2, Cyclin-A2, 5-methyl-7-phenyl-N-(3,4,5-trimethoxyphenyl)imidazo[5,1-f][1,2,4]triazin-2-amine (3 entities in total)
機能のキーワードcdk, cyclin, atp-binding, cell cycle, cell division, kinase, mitosis, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, nucleus, transferase-cell cycle complex, transferase/cell cycle
由来する生物種Homo sapiens
細胞内の位置Cytoplasm, cytoskeleton, microtubule organizing center, centrosome P24941
Nucleus  P20248
ポリマー鎖数4
分子量合計128470.85
構造登録者
主引用文献
Cheung, M.,Kuntz, K.W.,Pobanz, M.,Salovich, J.M.,Wilson, B.J.,Andrews, C.W.,Shewchuk, L.M.,Epperly, A.H.,Hassler, D.F.,Leesnitzer, M.A.,Smith, J.L.,Smith, G.K.,Lansing, T.J.,Mook, R.A.
Imidazo[5,1-f][1,2,4]triazin-2-amines as novel inhibitors of polo-like kinase 1.
Bioorg.Med.Chem.Lett., 18:6214-6217, 2008
PubMed: 18929484 (主引用文献が同じPDBエントリー)
DOI: 10.1016/j.bmcl.2008.09.100
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (3.2 Å)
?

構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.27240.3%0.8%1.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード