3EOC

Cdk2/CyclinA complexed with a imidazo triazin-2-amine

3EOC の概要

• エントリーDOI: 10.2210/pdb3eoc/pdb
• 分子名称: Cell division protein kinase 2, Cyclin-A2, 5-methyl-7-phenyl-N-(3,4,5-trimethoxyphenyl)imidazo[5,1-f][1,2,4]triazin-2-amine (3 entities in total)
• 機能のキーワード: cdk, cyclin, atp-binding, cell cycle, cell division, kinase, mitosis, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, nucleus, transferase-cell cycle complex, transferase/cell cycle
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 128470.85

構造登録者

Cheung, M.,Kuntz, K.,Pobanz, M.,Salovich, J.,Wilson, B.,Andrews, W.,Shewchuk, L.,Epperly, A.,Hassler, D.,Leesnitzer, M.,Smith, J.,Smith, G.,Lansing, T.,Mook, R. (登録日: 2008-09-26, 公開日: 2008-11-04, 最終更新日: 2023-09-06)

• 主引用文献: Cheung, M.,Kuntz, K.W.,Pobanz, M.,Salovich, J.M.,Wilson, B.J.,Andrews, C.W.,Shewchuk, L.M.,Epperly, A.H.,Hassler, D.F.,Leesnitzer, M.A.,Smith, J.L.,Smith, G.K.,Lansing, T.J.,Mook, R.A.; Imidazo[5,1-f][1,2,4]triazin-2-amines as novel inhibitors of polo-like kinase 1.; Bioorg.Med.Chem.Lett., 18:6214-6217, 2008; PubMed: 18929484; DOI: 10.1016/j.bmcl.2008.09.100

実験手法

X-RAY DIFFRACTION (3.2 Å)