3EO9

Crystal structure the Fab fragment of Efalizumab

Summary for 3EO9

• Entry DOI: 10.2210/pdb3eo9/pdb
• Related: 3EOA 3EOB
• Descriptor: Efalizumab Fab fragment, light chain, Efalizumab Fab fragment, heavy chain (3 entities in total)
• Functional Keywords: efalizumab, fab, antibody, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 2
• Total formula weight: 47058.57

Authors

Li, S.,Ding, J. (deposition date: 2008-09-26, release date: 2009-04-14, Last modification date: 2023-11-01)

• Primary citation: Li, S.,Wang, H.,Peng, B.,Zhang, M.,Zhang, D.,Hou, S.,Guo, Y.,Ding, J.; Efalizumab binding to the LFA-1 alphaL I domain blocks ICAM-1 binding via steric hindrance.; Proc.Natl.Acad.Sci.USA, 106:4349-4354, 2009; PubMed: 19258452; DOI: 10.1073/pnas.0810844106

Experimental method

X-RAY DIFFRACTION (1.8 Å)