3ENE

Complex of PI3K gamma with an inhibitor

3ENE の概要

分子名称Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 1-methyl-3-naphthalen-2-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine (3 entities in total)
機能のキーワードlipid kinase, phosphoinositide, inhibitor, 3-kinase, signaling, pyrazolopyrimidine, pik-208, s2, kinase, transferase
由来する生物種Homo sapiens (Human)
ポリマー鎖数1
分子量合計110071.37
構造登録者
Apsel, B.,Blair, J.A.,Gonzalez, B.Z.,Nazif, T.M.,Feldman, M.E.,Williams, R.L.,Shokat, K.M.,Knight, Z.A. (登録日: 2008-09-25, 公開日: 2008-10-14, 最終更新日: 2011-07-13)
主引用文献
Apsel, B.,Blair, J.A.,Gonzalez, B.,Nazif, T.M.,Feldman, M.E.,Aizenstein, B.,Hoffman, R.,Williams, R.L.,Shokat, K.M.,Knight, Z.A.
Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases
Nat.Chem.Biol., 4:691-699, 2008
PubMed: 18849971 (主引用文献が同じPDBエントリー)
DOI: 10.1038/nchembio.117
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.4 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.27181.3%14.1%3.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード