3EN7

Targeted polypharmacology: crystal structure of the c-Src kinase domain in complex with S1, a multitargeted kinase inhibitor

3EN7 の概要

• エントリーDOI: 10.2210/pdb3en7/pdb
• 関連するPDBエントリー: 3EN4 3EN5 3EN6
• 分子名称: Proto-oncogene tyrosine-protein kinase Src, 3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL (3 entities in total)
• 機能のキーワード: src, tyrosine, kinase, polypharmacology, inhibitor, multitarget, phosphoinositide, transferase, signaling, pyrazolopyrimidine, kinase-inhibitor complex, atp-binding, lipoprotein, myristate, nucleotide-binding, phosphoprotein, proto-oncogene, sh2 domain, sh3 domain, tyrosine-protein kinase
• 由来する生物種: Gallus gallus (bantam,chickens)
• 細胞内の位置: Cell membrane : P00523
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 65722.59

構造登録者

Blair, J.A.,Apsel, B.,Knight, Z.A.,Shokat, K.M. (登録日: 2008-09-25, 公開日: 2008-10-14, 最終更新日: 2024-02-21)

• 主引用文献: Apsel, B.,Blair, J.A.,Gonzalez, B.,Nazif, T.M.,Feldman, M.E.,Aizenstein, B.,Hoffman, R.,Williams, R.L.,Shokat, K.M.,Knight, Z.A.; Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases.; Nat.Chem.Biol., 4:691-699, 2008; PubMed: 18849971; DOI: 10.1038/nchembio.117

実験手法

X-RAY DIFFRACTION (2.81 Å)