3EMO

Crystal structure of transmembrane Hia 973-1098

3EMO の概要

• エントリーDOI: 10.2210/pdb3emo/pdb
• 関連するPDBエントリー: 1s7m 2gr7 2gr8 3EMF 3EMI
• 分子名称: Hia (Adhesin) (1 entity in total)
• 機能のキーワード: transmembrane, outer membrane, hia adhesin, trimeric autotransporter, membrane protein-cell adhesion complex, membrane protein/cell adhesion
• 由来する生物種: Haemophilus influenzae
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 48957.01

構造登録者

Meng, G.,Waksman, G. (登録日: 2008-09-24, 公開日: 2008-11-04, 最終更新日: 2023-11-01)

主引用文献

Meng, G.,St Geme, J.W.,Waksman, G.
Repetitive Architecture of the Haemophilus influenzae Hia Trimeric Autotransporter
J.Mol.Biol., 384:824-836, 2008

PubMed Abstract: The Hia autotransporter of Haemophilus influenzae belongs to the trimeric autotransporter subfamily and mediates bacterial adherence to the respiratory epithelium. In this report, we show that the structure of Hia is characterized by a modular architecture containing repeats of structurally distinct domains. Comparison of the structures of HiaBD1 and HiaBD2 adhesive repeats and a nonadhesive repeat (a novel fold) shed light on the structural determinants of Hia adhesive function. Examination of the structure of an extended version of the Hia translocator domain revealed the structural transition between the C-terminal translocator domain and the N-terminal passenger domain, highlighting a highly intertwined domain that is ubiquitous among trimeric autotransporters. Overall, this study provides important insights into the mechanism of Hia adhesive activity and the overall structure of trimeric autotransporters.

PubMed: 18948113
DOI: 10.1016/j.jmb.2008.09.085

実験手法

X-RAY DIFFRACTION (3 Å)