3EMG

Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK)

3EMG の概要

• エントリーDOI: 10.2210/pdb3emg/pdb
• 分子名称: Tyrosine-protein kinase SYK, 2-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-N-[(1S)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamide (3 entities in total)
• 機能のキーワード: kinase, syk, alternative splicing, atp-binding, host-virus interaction, nucleotide-binding, phosphoprotein, polymorphism, sh2 domain, transferase, tyrosine-protein kinase, ubl conjugation
• 由来する生物種: Homo sapiens
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34106.22

構造登録者

Ter Haar, E. (登録日: 2008-09-24, 公開日: 2008-12-02, 最終更新日: 2024-04-03)

• 主引用文献: Farmer, L.J.,Bemis, G.,Britt, S.D.,Cochran, J.,Connors, M.,Harrington, E.M.,Hoock, T.,Markland, W.,Nanthakumar, S.,Taslimi, P.,Ter Haar, E.,Wang, J.,Zhaveri, D.,Salituro, F.G.; Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK).; Bioorg.Med.Chem.Lett., 18:6231-6235, 2008; PubMed: 18938080; DOI: 10.1016/j.bmcl.2008.09.106

実験手法

X-RAY DIFFRACTION (2.6 Å)