3EM6
Crystal structure of I50L/A71V mutant of hiv-1 protease in complex with inhibitor darunavir
Summary for 3EM6
Entry DOI | 10.2210/pdb3em6/pdb |
Related | 3EM3 3EM4 |
Descriptor | Protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, PHOSPHATE ION, ... (5 entities in total) |
Functional Keywords | protease inhibitor, hyper susceptibility, drug resistance, hiv, darunavir, aids, hydrolase, protease |
Biological source | HIV-1 M:B_ARV2/SF2 (HIV-1) |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369 |
Total number of polymer chains | 2 |
Total formula weight | 22859.28 |
Authors | Royer, C.J.,King, N.M.,Prabu-Jeyabalan, M.,Ng, C.,Nalivaika, E.A.,Schiffer, C.A. (deposition date: 2008-09-23, release date: 2009-09-01, Last modification date: 2024-03-13) |
Primary citation | Prabu-Jeyabalan, M.,Ng, C.,King, N.M.,Bandaranayake, R.,Nalivaika, E.A.,Schiffer, C.A. Kinetic and structural studies on atazanavir specific I50L drug-resistant HIV-1 protease mutant. To be Published, |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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