3EM6

Crystal structure of I50L/A71V mutant of hiv-1 protease in complex with inhibitor darunavir

3EM6 の概要

関連するPDBエントリー3EM4 3EM3
分子名称Protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, PHOSPHATE ION, ... (5 entities in total)
機能のキーワードprotease inhibitor, hyper susceptibility, drug resistance, hiv, darunavir, aids, hydrolase, protease
由来する生物種HIV-1 M:B_ARV2/SF2 (HIV-1)
詳細
細胞内の位置Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion  P03369
ポリマー鎖数2
分子量合計22859.28
構造登録者
Royer, C.J.,King, N.M.,Prabu-Jeyabalan, M.,Ng, C.,Nalivaika, E.A.,Schiffer, C.A. (登録日: 2008-09-23, 公開日: 2009-09-01, 最終更新日: 2017-10-25)
主引用文献
Prabu-Jeyabalan, M.,Ng, C.,King, N.M.,Bandaranayake, R.,Nalivaika, E.A.,Schiffer, C.A.
Kinetic and structural studies on atazanavir specific I50L drug-resistant HIV-1 protease mutant.
To be Published,
実験手法
X-RAY DIFFRACTION (2.1 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.25230.5%3.3%2.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード