3EM6

Crystal structure of I50L/A71V mutant of hiv-1 protease in complex with inhibitor darunavir

3EM6 の概要

• エントリーDOI: 10.2210/pdb3em6/pdb
• 関連するPDBエントリー: 3EM3 3EM4
• 分子名称: Protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, PHOSPHATE ION, ... (5 entities in total)
• 機能のキーワード: protease inhibitor, hyper susceptibility, drug resistance, hiv, darunavir, aids, hydrolase, protease
• 由来する生物種: HIV-1 M:B_ARV2/SF2 (HIV-1)
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22859.28

構造登録者

Royer, C.J.,King, N.M.,Prabu-Jeyabalan, M.,Ng, C.,Nalivaika, E.A.,Schiffer, C.A. (登録日: 2008-09-23, 公開日: 2009-09-01, 最終更新日: 2024-03-13)

• 主引用文献: Prabu-Jeyabalan, M.,Ng, C.,King, N.M.,Bandaranayake, R.,Nalivaika, E.A.,Schiffer, C.A.; Kinetic and structural studies on atazanavir specific I50L drug-resistant HIV-1 protease mutant.; To be Published,

実験手法

X-RAY DIFFRACTION (2.1 Å)