3ELC

Crystal structure of 2C-methyl-D-erythritol 2,4-clycodiphosphate synthase complexed with ligand

3ELC の概要

• エントリーDOI: 10.2210/pdb3elc/pdb
• 分子名称: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, ZINC ION, 4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-fluoro-pyrimidin-2-one, ... (5 entities in total)
• 機能のキーワード: mecdp-synthase, isoprene biosynthesis, lyase, magnesium, manganese, metal-binding
• 由来する生物種: Escherichia coli K-12
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 54022.88

構造登録者

Hunter, W.N.,Ramsden, N.L.,Ulaganathan, V. (登録日: 2008-09-22, 公開日: 2009-08-25, 最終更新日: 2023-11-01)

• 主引用文献: Ramsden, N.L.,Buetow, L.,Dawson, A.,Kemp, L.A.,Ulaganathan, V.,Brenk, R.,Klebe, G.,Hunter, W.N.; A structure-based approach to ligand discovery for 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase: a target for antimicrobial therapy; J.Med.Chem., 52:2531-2542, 2009; PubMed: 19320487; DOI: 10.1021/jm801475n

実験手法

X-RAY DIFFRACTION (2.5 Å)