3EKN
Insulin receptor kinase complexed with an inhibitor
Summary for 3EKN
Entry DOI | 10.2210/pdb3ekn/pdb |
Related | 3EKK 3ELJ |
Descriptor | Insulin receptor, 2-fluoro-6-{[2-({2-methoxy-4-[4-(1-methylethyl)piperazin-1-yl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide (3 entities in total) |
Functional Keywords | insulin, tyrosine kinase, atp-binding, carbohydrate metabolism, cleavage on pair of basic residues, diabetes mellitus, disease mutation, glycoprotein, kinase, membrane, nucleotide-binding, phosphoprotein, receptor, transferase, transmembrane, tyrosine-protein kinase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P06213 |
Total number of polymer chains | 1 |
Total formula weight | 35368.38 |
Authors | Chamberlain, S.,Atkins, C.,Deanda, F.,Dumble, M.,Gerding, R.,Groy, A.,Korenchuk, S.,Kumar, R.,Lei, H.,Mook, R.,Moorthy, G.,Redman, A.,Rowland, J.,Shewchuk, L. (deposition date: 2008-09-19, release date: 2008-12-30, Last modification date: 2023-08-30) |
Primary citation | Chamberlain, S.D.,Redman, A.M.,Wilson, J.W.,Deanda, F.,Shotwell, J.B.,Gerding, R.,Lei, H.,Yang, B.,Stevens, K.L.,Hassell, A.M.,Shewchuk, L.M.,Leesnitzer, M.A.,Smith, J.L.,Sabbatini, P.,Atkins, C.,Groy, A.,Rowand, J.L.,Kumar, R.,Mook, R.A.,Moorthy, G.,Patnaik, S. Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity. Bioorg.Med.Chem.Lett., 19:360-364, 2009 Cited by PubMed: 19071018DOI: 10.1016/j.bmcl.2008.11.077 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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