3EHY

Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor (R)-2-(4-methoxyphenylsulfonamido)propanoic acid

3EHY の概要

• エントリーDOI: 10.2210/pdb3ehy/pdb
• 関連するPDBエントリー: 3EHX
• 分子名称: Macrophage metalloelastase, ZINC ION, CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: matrix metalloproteinase, mmp12, elastase, complex (elastase-inhibitor), metallo elastase, calcium, extracellular matrix, glycoprotein, hydrolase, metal-binding, metalloprotease, polymorphism, protease, secreted, zinc, zymogen
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Secreted, extracellular space, extracellular matrix (Probable): P39900
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17994.81

構造登録者

Calderone, V. (登録日: 2008-09-15, 公開日: 2009-05-19, 最終更新日: 2023-11-01)

• 主引用文献: Dragoni, E.,Calderone, V.,Fragai, M.,Jaiswal, R.,Luchinat, C.,Nativi, C.; Biotin-tagged probes for MMP expression and activation: design, synthesis, and binding properties; Bioconjug.Chem., 20:719-727, 2009; PubMed: 19275207; DOI: 10.1021/bc8003827

実験手法

X-RAY DIFFRACTION (1.9 Å)