3EGH

Crystal structure of a complex between Protein Phosphatase 1 alpha (PP1), the PP1 binding and PDZ domains of Spinophilin and the small natural molecular toxin Nodularin-R

3EGH の概要

• エントリーDOI: 10.2210/pdb3egh/pdb
• 関連するPDBエントリー: 1FJM 1S70 2G5M 3E7A 3EGG 3HVQ
• 関連するBIRD辞書のPRD_ID: PRD_000214
• 分子名称: Serine/threonine-protein phosphatase PP1-alpha catalytic subunit, Spinophilin, nodularin R, ... (6 entities in total)
• 機能のキーワード: pp1, serine/threonine phosphatase, post synaptic density, inhibitor, carbohydrate metabolism, cell cycle, cell division, glycogen metabolism, hydrolase, iron, manganese, metal-binding, phosphoprotein, protein phosphatase, actin-binding, cell junction, cell projection, cytoskeleton, developmental protein, differentiation, neurogenesis, nucleus, synapse, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cytoplasm: P62136; Cytoplasm, cytoskeleton: O35274
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 114118.92

構造登録者

Ragusa, M.J.,Page, R.,Peti, W. (登録日: 2008-09-10, 公開日: 2010-03-23, 最終更新日: 2023-11-15)

• 主引用文献: Ragusa, M.J.,Dancheck, B.,Critton, D.A.,Nairn, A.C.,Page, R.,Peti, W.; Spinophilin directs protein phosphatase 1 specificity by blocking substrate binding sites.; Nat.Struct.Mol.Biol., 17:459-464, 2010; PubMed: 20305656; DOI: 10.1038/nsmb.1786

実験手法

X-RAY DIFFRACTION (2 Å)