3EFW

Structure of AuroraA with pyridyl-pyrimidine urea inhibitor

3EFW の概要

• エントリーDOI: 10.2210/pdb3efw/pdb
• 分子名称: Serine/threonine-protein kinase 6, 1-[3-methyl-4-({3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl}oxy)phenyl]-3-[3-(trifluoromethyl)phenyl]urea, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: auroraa, stk6_human, atp-binding, cell cycle, kinase, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm, cytoskeleton, centrosome: O14965
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 63254.45

構造登録者

Bellon, S.F.,Cee, V.,Hughes, P.,Geuns-Meyer, S.,Whittington, D. (登録日: 2008-09-10, 公開日: 2008-12-23, 最終更新日: 2024-02-21)

• 主引用文献: Cee, V.J.,Cheng, A.C.,Romero, K.,Bellon, S.,Mohr, C.,Whittington, D.A.,Bak, A.,Bready, J.,Caenepeel, S.,Coxon, A.,Deak, H.L.,Fretland, J.,Gu, Y.,Hodous, B.L.,Huang, X.,Kim, J.L.,Lin, J.,Long, A.M.,Nguyen, H.,Olivieri, P.R.,Patel, V.F.,Wang, L.,Zhou, Y.,Hughes, P.,Geuns-Meyer, S.; Pyridyl-pyrimidine benzimidazole derivatives as potent, selective, and orally bioavailable inhibitors of Tie-2 kinase.; Bioorg.Med.Chem.Lett., 19:424-427, 2009; PubMed: 19062275; DOI: 10.1016/j.bmcl.2008.11.056

実験手法

X-RAY DIFFRACTION (2.29 Å)