3EEJ

Candida glabrata Dihydrofolate Reductase complexed with 2,4-diamino-5-[3-methyl-3-(3-methoxy-5-phenylphenyl)prop-1-ynyl]-6-methylpyrimidine(UCP111D) and NADPH

3EEJ の概要

• エントリーDOI: 10.2210/pdb3eej/pdb
• 関連するPDBエントリー: 3EEK 3EEL 3EEM
• 分子名称: Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-[(3R)-3-(5-methoxybiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine, ... (4 entities in total)
• 機能のキーワード: enzyme, oxidoreductase
• 由来する生物種: Candida glabrata (yeast)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 55062.38

構造登録者

Liu, J.,Anderson, A. (登録日: 2008-09-04, 公開日: 2009-08-18, 最終更新日: 2024-02-21)

• 主引用文献: Liu, J.,Bolstad, D.B.,Smith, A.E.,Priestley, N.D.,Wright, D.L.,Anderson, A.C.; Probing the active site of Candida glabrata dihydrofolate reductase with high resolution crystal structures and the synthesis of new inhibitors; Chem.Biol.Drug Des., 73:62-74, 2009; PubMed: 19152636; DOI: 10.1111/j.1747-0285.2008.00745.x

実験手法

X-RAY DIFFRACTION (2.11 Å)