3EC0

High Resolution HIV-2 Protease Structure in Complex with Antiviral Inhibitor GRL-06579A

3EC0 の概要

• エントリーDOI: 10.2210/pdb3ec0/pdb
• 関連するPDBエントリー: 3EBZ
• 分子名称: Protease, (3AS,5R,6AR)-HEXAHYDRO-2H-CYCLOPENTA[B]FURAN-5-YL (2S,3S)-3-HYDROXY-4-(4-(HYDROXYMETHYL)-N-ISOBUTYLPHENYLSULFONAMIDO)-1-PHENYLBUTAN-2-YLCARBAMATE, IMIDAZOLE, ... (7 entities in total)
• 機能のキーワード: hiv-2, aspartic protease, inhibitor, protease-inhibitor complex, hydrolase
• 由来する生物種: Human immunodeficiency virus type 2 (ISOLATE ROD)
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04584
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 23392.59

構造登録者

Kovalevsky, A.Y.,Weber, I.T. (登録日: 2008-08-28, 公開日: 2008-09-16, 最終更新日: 2023-11-01)

• 主引用文献: Kovalevsky, A.Y.,Louis, J.M.,Aniana, A.,Ghosh, A.K.,Weber, I.T.; Structural evidence for effectiveness of darunavir and two related antiviral inhibitors against HIV-2 protease; J.Mol.Biol., 384:178-192, 2008; PubMed: 18834890; DOI: 10.1016/j.jmb.2008.09.031

実験手法

X-RAY DIFFRACTION (1.18 Å)