3EBI

Structure of the M1 Alanylaminopeptidase from malaria complexed with the phosphinate dipeptide analog

3EBI の概要

• エントリーDOI: 10.2210/pdb3ebi/pdb
• 関連するPDBエントリー: 3EBG 3EBH
• 分子名称: M1 family aminopeptidase, ZINC ION, (2S)-3-[(R)-[(1S)-1-amino-3-phenylpropyl](hydroxy)phosphoryl]-2-benzylpropanoic acid, ... (6 entities in total)
• 機能のキーワード: hydrolase, aminopeptidase, metal-binding, metalloprotease, protease, hydrolase inhibitor
• 由来する生物種: Plasmodium falciparum
• 細胞内の位置: Cytoplasm: O96935
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 104745.19

構造登録者

McGowan, S.,Porter, C.J.,Buckle, A.M.,Whisstock, J.C. (登録日: 2008-08-27, 公開日: 2009-01-27, 最終更新日: 2024-02-21)

• 主引用文献: McGowan, S.,Porter, C.J.,Lowther, J.,Stack, C.M.,Golding, S.J.,Skinner-Adams, T.S.,Trenholme, K.R.,Teuscher, F.,Donnelly, S.M.,Grembecka, J.,Mucha, A.,Kafarski, P.,Degori, R.,Buckle, A.M.,Gardiner, D.L.,Whisstock, J.C.,Dalton, J.P.; Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase; Proc.Natl.Acad.Sci.USA, 106:2537-2542, 2009; PubMed: 19196988; DOI: 10.1073/pnas.0807398106

実験手法

X-RAY DIFFRACTION (2 Å)