3EB1

Crystal structure PTP1B complex with small molecule inhibitor LZP-25

3EB1 の概要

• エントリーDOI: 10.2210/pdb3eb1/pdb
• 関連するPDBエントリー: 3EAX
• 分子名称: Tyrosine-protein phosphatase non-receptor type 1, 4-[3-(dibenzylamino)phenyl]-2,4-dioxobutanoic acid (3 entities in total)
• 機能のキーワード: protein tyrosine phosphatase, ptp1b, inhibitor, acetylation, endoplasmic reticulum, hydrolase, membrane, oxidation, phosphoprotein, polymorphism, protein phosphatase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37753.07

構造登録者

Liu, S.,Zheng, L.-F.,Wu, L.,Yu, X.,Xue, T.,Gunawan, A.M.,Long, Y.-Q.,Zhang, Z.-Y. (登録日: 2008-08-26, 公開日: 2009-07-07, 最終更新日: 2024-02-21)

• 主引用文献: Liu, S.,Zeng, L.F.,Wu, L.,Yu, X.,Xue, T.,Gunawan, A.M.,Long, Y.Q.,Zhang, Z.Y.; Targeting inactive enzyme conformation: aryl diketoacid derivatives as a new class of PTP1B inhibitors.; J.Am.Chem.Soc., 130:17075-17084, 2008; PubMed: 19012396; DOI: 10.1021/ja8068177

実験手法

X-RAY DIFFRACTION (2.4 Å)