3E65
Murine INOS dimer with HEME, pterin and inhibitor AR-C120011
Summary for 3E65
Entry DOI | 10.2210/pdb3e65/pdb |
Descriptor | Nitric oxide synthase, inducible, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (5 entities in total) |
Functional Keywords | dimer, inducible nitric oxide synthase, calmodulin-binding, fad, fmn, heme, iron, metal-binding, nadp, oxidoreductase, polymorphism, zinc |
Biological source | Mus musculus (mouse) |
Total number of polymer chains | 2 |
Total formula weight | 102692.21 |
Authors | Rosenfeld, R.J.,Garcin, E.D.,Getzoff, E.D. (deposition date: 2008-08-14, release date: 2008-10-07, Last modification date: 2023-08-30) |
Primary citation | Garcin, E.D.,Arvai, A.S.,Rosenfeld, R.J.,Kroeger, M.D.,Crane, B.R.,Andersson, G.,Andrews, G.,Hamley, P.J.,Mallinder, P.R.,Nicholls, D.J.,St-Gallay, S.A.,Tinker, A.C.,Gensmantel, N.P.,Mete, A.,Cheshire, D.R.,Connolly, S.,Stuehr, D.J.,Aberg, A.,Wallace, A.V.,Tainer, J.A.,Getzoff, E.D. Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase. Nat.Chem.Biol., 4:700-707, 2008 Cited by PubMed: 18849972DOI: 10.1038/nchembio.115 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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