Crystal structure of human insulin degrading enzyme in complex with transforming growth factor-alpha

Summary for 3E50

DescriptorInsulin-degrading enzyme, Protransforming growth factor alpha, ZINC ION, ... (4 entities in total)
Functional Keywordside, tgf-alpha, cytoplasm, hydrolase, metal-binding, metalloprotease, polymorphism, protease, zinc, cell membrane, egf-like domain, glycoprotein, growth factor, lipoprotein, membrane, mitogen, palmitate, secreted, transmembrane, hydrolase-hormone complex, hydrolase/hormone
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm P14735
Transforming growth factor alpha: Secreted, extracellular space. Protransforming growth factor alpha: Cell membrane; Single-pass type I membrane protein P01135
Total number of polymer chains4
Total molecular weight240681.59
Guo, Q.,Manolopoulou, M.,Tang, W.-J. (deposition date: 2008-08-12, release date: 2009-08-18, Last modification date: 2011-07-13)
Primary citation
Guo, Q.,Manolopoulou, M.,Bian, Y.,Schilling, A.B.,Tang, W.J.
Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-alpha, and Amylin by Human Insulin-Degrading Enzyme.
J.Mol.Biol., 395:430-443, 2010
PubMed: 19896952 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2009.10.072
MImport into Mendeley
Experimental method
NMR Information

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.23480.2%8.6%2.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution