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3E50

Crystal structure of human insulin degrading enzyme in complex with transforming growth factor-alpha

Summary for 3E50
Entry DOI10.2210/pdb3e50/pdb
Related3E4Z
DescriptorInsulin-degrading enzyme, Protransforming growth factor alpha, ZINC ION, ... (4 entities in total)
Functional Keywordside, tgf-alpha, cytoplasm, hydrolase, metal-binding, metalloprotease, polymorphism, protease, zinc, cell membrane, egf-like domain, glycoprotein, growth factor, lipoprotein, membrane, mitogen, palmitate, secreted, transmembrane, hydrolase-hormone complex, hydrolase/hormone
Biological sourceHomo sapiens (Human)
More
Cellular locationCytoplasm: P14735
Transforming growth factor alpha: Secreted, extracellular space. Protransforming growth factor alpha: Cell membrane; Single-pass type I membrane protein: P01135
Total number of polymer chains4
Total formula weight240681.59
Authors
Guo, Q.,Manolopoulou, M.,Tang, W.-J. (deposition date: 2008-08-12, release date: 2009-08-18, Last modification date: 2024-02-21)
Primary citationGuo, Q.,Manolopoulou, M.,Bian, Y.,Schilling, A.B.,Tang, W.J.
Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-alpha, and Amylin by Human Insulin-Degrading Enzyme.
J.Mol.Biol., 395:430-443, 2010
Cited by
PubMed: 19896952
DOI: 10.1016/j.jmb.2009.10.072
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

217705

數據於2024-03-27公開中

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