3E50

Crystal structure of human insulin degrading enzyme in complex with transforming growth factor-alpha

3E50 の概要

• エントリーDOI: 10.2210/pdb3e50/pdb
• 関連するPDBエントリー: 3E4Z
• 分子名称: Insulin-degrading enzyme, Protransforming growth factor alpha, ZINC ION, ... (4 entities in total)
• 機能のキーワード: ide, tgf-alpha, cytoplasm, hydrolase, metal-binding, metalloprotease, polymorphism, protease, zinc, cell membrane, egf-like domain, glycoprotein, growth factor, lipoprotein, membrane, mitogen, palmitate, secreted, transmembrane, hydrolase-hormone complex, hydrolase/hormone
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cytoplasm: P14735; Transforming growth factor alpha: Secreted, extracellular space. Protransforming growth factor alpha: Cell membrane; Single-pass type I membrane protein: P01135
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 240681.59

構造登録者

Guo, Q.,Manolopoulou, M.,Tang, W.-J. (登録日: 2008-08-12, 公開日: 2009-08-18, 最終更新日: 2024-02-21)

• 主引用文献: Guo, Q.,Manolopoulou, M.,Bian, Y.,Schilling, A.B.,Tang, W.J.; Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-alpha, and Amylin by Human Insulin-Degrading Enzyme.; J.Mol.Biol., 395:430-443, 2010; PubMed: 19896952; DOI: 10.1016/j.jmb.2009.10.072

実験手法

X-RAY DIFFRACTION (2.3 Å)