3DYA
HIV-1 RT with non-nucleoside inhibitor annulated Pyrazole 1
Summary for 3DYA
Entry DOI | 10.2210/pdb3dya/pdb |
Related | 3E01 |
Descriptor | REVERSE TRANSCRIPTASE/RIBONUCLEASE H, p51 RT, 3-[6-bromo-2-fluoro-3-(1H-pyrazolo[3,4-c]pyridazin-3-ylmethyl)phenoxy]-5-chlorobenzonitrile, ... (4 entities in total) |
Functional Keywords | pr160gag-pol, reverse transcriptase/ribonuclease h, p66 rt, p51 rt, transferase |
Biological source | HIV-1 M:B_HXB2R (HIV-1) More |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 P04585 |
Total number of polymer chains | 2 |
Total formula weight | 116567.84 |
Authors | Harris, S.F.,Villasenor, A. (deposition date: 2008-07-25, release date: 2008-11-25, Last modification date: 2024-02-21) |
Primary citation | Sweeney, Z.K.,Harris, S.F.,Arora, S.F.,Javanbakht, H.,Li, Y.,Fretland, J.,Davidson, J.P.,Billedeau, J.R.,Gleason, S.K.,Hirschfeld, D.,Kennedy-Smith, J.J.,Mirzadegan, T.,Roetz, R.,Smith, M.,Sperry, S.,Suh, J.M.,Wu, J.,Tsing, S.,Villasenor, A.G.,Paul, A.,Su, G.,Heilek, G.,Hang, J.Q.,Zhou, A.S.,Jernelius, J.A.,Zhang, F.J.,Klumpp, K. Design of annulated pyrazoles as inhibitors of HIV-1 reverse transcriptase J.Med.Chem., 51:7449-7458, 2008 Cited by PubMed: 19007201DOI: 10.1021/jm800527x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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