3DY3

Crystal structure of yeast 20S proteasome in complex with the epimer form of spirolactacystin

3DY3 の概要

• エントリーDOI: 10.2210/pdb3dy3/pdb
• 関連するPDBエントリー: 1RYP 3DY4
• 分子名称: Proteasome component Y7, Proteasome component C11, Proteasome component PRE2, ... (16 entities in total)
• 機能のキーワード: proteasome, inhibitor, protein degradation, ubiquitin-proteasome-pathway, cytoplasm, hydrolase, nucleus, protease, threonine protease, ubl conjugation, phosphoprotein, zymogen
• 由来する生物種: Saccharomyces cerevisiae (Baker's yeast); 詳細
• 細胞内の位置: Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451
• タンパク質・核酸の鎖数: 28
• 化学式量合計: 704668.73

構造登録者

Groll, M.,Balskus, E.,Jacobsen, E. (登録日: 2008-07-25, 公開日: 2008-11-04, 最終更新日: 2024-03-13)

• 主引用文献: Groll, M.,Balskus, E.P.,Jacobsen, E.N.; Structural analysis of spiro beta-lactone proteasome inhibitors.; J.Am.Chem.Soc., 130:14981-14983, 2008; PubMed: 18928262; DOI: 10.1021/ja806059t

実験手法

X-RAY DIFFRACTION (2.81 Å)