3DXD

Crystal structure of the intracellular domain of human APP (T668E mutant) in complex with Fe65-PTB2

3DXD の概要

• エントリーDOI: 10.2210/pdb3dxd/pdb
• 関連するPDBエントリー: 3DXC 3DXE
• 分子名称: Amyloid beta A4 protein-binding family B member 1, Amyloid beta A4 protein (3 entities in total)
• 機能のキーワード: alzheimer's disease, app, aicd, fe65, ptb domain, alzheimer disease, amyloid, apoptosis, cell adhesion, coated pit, disease mutation, endocytosis, glycoprotein, heparin-binding, iron, membrane, metal-binding, notch signaling pathway, phosphoprotein, protease inhibitor, proteoglycan, serine protease inhibitor, transmembrane, protein binding
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cell membrane: O00213; Membrane; Single-pass type I membrane protein: P05067
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 39166.41

構造登録者

Radzimanowski, J.,Sinning, I.,Wild, K. (登録日: 2008-07-24, 公開日: 2008-09-16, 最終更新日: 2024-02-21)

• 主引用文献: Radzimanowski, J.,Simon, B.,Sattler, M.,Beyreuther, K.,Sinning, I.,Wild, K.; Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65-PTB2.; Embo Rep., 9:1134-1140, 2008; PubMed: 18833287; DOI: 10.1038/embor.2008.188

実験手法

X-RAY DIFFRACTION (2.2 Å)