3DV3

MEK1 with PF-04622664 Bound

3DV3 の概要

• エントリーDOI: 10.2210/pdb3dv3/pdb
• 分子名称: Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ... (6 entities in total)
• 機能のキーワード: kinase, kinase inhibitors, mek, atp-binding, disease mutation, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, tyrosine-protein kinase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : Q02750
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36961.17

構造登録者

Kazmirski, S.L.,Kothe, M.,Ding, Y.-H. (登録日: 2008-07-18, 公開日: 2009-07-21, 最終更新日: 2024-02-21)

• 主引用文献: Tecle, H.,Shao, J.,Li, Y.,Kothe, M.,Kazmirski, S.,Penzotti, J.,Ding, Y.H.,Ohren, J.,Moshinsky, D.,Coli, R.,Jhawar, N.,Bora, E.,Jacques-O'Hagan, S.,Wu, J.; Beyond the MEK-pocket: can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK?; Bioorg.Med.Chem.Lett., 19:226-229, 2009; PubMed: 19019675; DOI: 10.1016/j.bmcl.2008.10.108

実験手法

X-RAY DIFFRACTION (2.3 Å)