3DUE

CRYSTAL STRUCTURE OF A PUTATIVE PERIPLASMIC PROTEIN FROM DUF2874 FAMILY (BVU_2987) FROM BACTEROIDES VULGATUS ATCC 8482 AT 1.85 A RESOLUTION

3DUE の概要

• エントリーDOI: 10.2210/pdb3due/pdb
• 分子名称: Putative periplasmic protein, CACODYLATE ION (3 entities in total)
• 機能のキーワード: putative periplasmic protein, structural genomics, joint center for structural genomics, jcsg, protein structure initiative, psi-2, unknown function
• 由来する生物種: Bacteroides vulgatus ATCC 8482
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15026.19

構造登録者

Joint Center for Structural Genomics (JCSG) (登録日: 2008-07-17, 公開日: 2008-08-05, 最終更新日: 2024-10-09)

主引用文献

Das, D.,Finn, R.D.,Carlton, D.,Miller, M.D.,Abdubek, P.,Astakhova, T.,Axelrod, H.L.,Bakolitsa, C.,Chen, C.,Chiu, H.J.,Chiu, M.,Clayton, T.,Deller, M.C.,Duan, L.,Ellrott, K.,Ernst, D.,Farr, C.L.,Feuerhelm, J.,Grant, J.C.,Grzechnik, A.,Han, G.W.,Jaroszewski, L.,Jin, K.K.,Klock, H.E.,Knuth, M.W.,Kozbial, P.,Krishna, S.S.,Kumar, A.,Marciano, D.,McMullan, D.,Morse, A.T.,Nigoghossian, E.,Nopakun, A.,Okach, L.,Puckett, C.,Reyes, R.,Rife, C.L.,Sefcovic, N.,Tien, H.J.,Trame, C.B.,van den Bedem, H.,Weekes, D.,Wooten, T.,Xu, Q.,Hodgson, K.O.,Wooley, J.,Elsliger, M.A.,Deacon, A.M.,Godzik, A.,Lesley, S.A.,Wilson, I.A.
The structure of BVU2987 from Bacteroides vulgatus reveals a superfamily of bacterial periplasmic proteins with possible inhibitory function.
Acta Crystallogr.,Sect.F, 66:1265-1273, 2010

PubMed Abstract: Proteins that contain the DUF2874 domain constitute a new Pfam family PF11396. Members of this family have predominantly been identified in microbes found in the human gut and oral cavity. The crystal structure of one member of this family, BVU2987 from Bacteroides vulgatus, has been determined, revealing a β-lactamase inhibitor protein-like structure with a tandem repeat of domains. Sequence analysis and structural comparisons reveal that BVU2987 and other DUF2874 proteins are related to β-lactamase inhibitor protein, PepSY and SmpA_OmlA proteins and hence are likely to function as inhibitory proteins.

PubMed: 20944221
DOI: 10.1107/S1744309109046788

実験手法

X-RAY DIFFRACTION (1.85 Å)