3DSE

A potent peptidomimetic inhibitor of botulinum neurotoxin serotype A has a very different conformation than SNAP-25 substrate

3DSE の概要

• エントリーDOI: 10.2210/pdb3dse/pdb
• 関連するPDBエントリー: 1XTF 2ISG 3DS9 3DSE
• 分子名称: Botulinum neurotoxin type A, ZINC ION, NICKEL (II) ION, ... (4 entities in total)
• 機能のキーワード: snare, botulism, inhibition, metalloprotease, neurotransmission, neuromuscular junction, hydrolase, membrane, metal-binding, neurotoxin, pharmaceutical, protease, secreted, toxin, transmembrane, zinc
• 由来する生物種: Clostridium botulinum
• 細胞内の位置: Botulinum neurotoxin A light chain: Secreted. Botulinum neurotoxin A heavy chain: Secreted: A5HZZ9
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 47902.09

構造登録者

Zuniga, J.E.,Fenn, T. (登録日: 2008-07-11, 公開日: 2008-09-30, 最終更新日: 2024-02-21)

• 主引用文献: Zuniga, J.E.,Schmidt, J.J.,Fenn, T.,Burnett, J.C.,Arac, D.,Gussio, R.,Stafford, R.G.,Badie, S.S.,Bavari, S.,Brunger, A.T.; A Potent Peptidomimetic Inhibitor of Botulinum Neurotoxin Serotype A Has a Very Different Conformation than SNAP-25 Substrate; Structure, 16:1588-1597, 2008; PubMed: 18940613; DOI: 10.1016/j.str.2008.07.011

実験手法

X-RAY DIFFRACTION (1.9 Å)