3DQS

Structure of endothelial NOS heme domain in complex with a inhibitor (+-)-N1-{cis-4'-[(6"-amino-4"-methylpyridin-2"-yl)methyl]pyrrolidin-3'-yl}-N2-(4'-chlorobenzyl)ethane-1,2-diamine

3DQS の概要

• エントリーDOI: 10.2210/pdb3dqs/pdb
• 関連するPDBエントリー: 3B3O 3DQT
• 分子名称: Nitric oxide synthase, endothelial, CACODYLATE ION, ACETATE ION, ... (9 entities in total)
• 機能のキーワード: nitric oxide synthase heme enzyme inhibitor, blood coagulation, calmodulin-binding, cytoskeleton, fad, fmn, golgi apparatus, heme, iron, lipoprotein, membrane, metal-binding, myristate, nadp, oxidoreductase, palmitate, phosphoprotein
• 由来する生物種: Bos taurus (bovine)
• 細胞内の位置: Cell membrane: P29473
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 96813.03

構造登録者

Igarashi, J.,Li, H.,Poulos, T.L. (登録日: 2008-07-09, 公開日: 2009-03-31, 最終更新日: 2024-02-21)

• 主引用文献: Igarashi, J.,Li, H.,Jamal, J.,Ji, H.,Fang, J.,Lawton, G.R.,Silverman, R.B.,Poulos, T.L.; Crystal structures of constitutive nitric oxide synthases in complex with de novo designed inhibitors.; J.Med.Chem., 52:2060-2066, 2009; PubMed: 19296678; DOI: 10.1021/jm900007a

実験手法

X-RAY DIFFRACTION (2.03 Å)