3DPD

Achieving multi-isoform PI3K inhibition in a series of substituted 3,4-Dihydro-2H-benzo[1,4]oxazines

3DPD の概要

• エントリーDOI: 10.2210/pdb3dpd/pdb
• 関連するPDBエントリー: 1e8y
• 分子名称: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 5,5-dimethyl-2-morpholin-4-yl-5,6-dihydro-1,3-benzothiazol-7(4H)-one (2 entities in total)
• 機能のキーワード: phosphoinositide 3-kinase gamma, secondary messenger generation, pi3k, pi 3k, kinase, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 111022.52

構造登録者

Ceska, T.A. (登録日: 2008-07-08, 公開日: 2008-08-26, 最終更新日: 2023-11-01)

• 主引用文献: Perry, B.,Alexander, R.,Bennett, G.,Buckley, G.,Ceska, T.,Crabbe, T.,Dale, V.,Gowers, L.,Horsley, H.,James, L.,Jenkins, K.,Crepy, K.,Kulisa, C.,Lightfoot, H.,Lock, C.,Mack, S.,Morgan, T.,Nicolas, A.-L.,Pitt, W.,Sabin, V.,Wright, S.; Achieving multi-isoform PI3K inhibition in a series of substituted 3,4-dihydro-2H-benzo[1,4]oxazines; Bioorg.Med.Chem.Lett., 18:4700-4704, 2008; PubMed: 18644721; DOI: 10.1016/j.bmcl.2008.06.104

実験手法

X-RAY DIFFRACTION (2.85 Å)