3DP3

Crystal structure of (3R)-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ) from Helicobacter pylori in complex with compound 3q

Summary for 3DP3

• Entry DOI: 10.2210/pdb3dp3/pdb
• Related: 2GLL 3DOY 3DOZ 3DP0 3DP1 3DP2
• Descriptor: (3R)-hydroxymyristoyl-acyl carrier protein dehydratase, CHLORIDE ION, BENZAMIDINE, ... (5 entities in total)
• Functional Keywords: fabz complex, lyase
• Biological source: Helicobacter pylori (Campylobacter pylori)
• Cellular location: Cytoplasm (By similarity): Q5G940
• Total number of polymer chains: 6
• Total formula weight: 111110.65

Authors

Zhang, L.,He, L.,Liu, X.,Liu, H.,Shen, X.,Jiang, H. (deposition date: 2008-07-07, release date: 2009-05-05, Last modification date: 2023-11-01)

• Primary citation: He, L.,Zhang, L.,Liu, X.,Li, X.,Zheng, M.,Li, H.,Yu, K.,Chen, K.,Shen, X.,Jiang, H.,Liu, H.; Discovering potent inhibitors against the beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Helicobacter pylori: structure-based design, synthesis, bioassay, and crystal structure determination.; J.Med.Chem., 52:2465-2481, 2009; PubMed: 19309082; DOI: 10.1021/jm8015602

Experimental method

X-RAY DIFFRACTION (2.3 Å)