3DOP
Crystal structure of 5beta-reductase (AKR1D1) in complex with NADP+ and 5beta-dihydrotestosterone, Resolution 2.00A
Summary for 3DOP
Entry DOI | 10.2210/pdb3dop/pdb |
Related | 3CMF |
Descriptor | 3-oxo-5-beta-steroid 4-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-beta-DIHYDROTESTOSTERONE, ... (4 entities in total) |
Functional Keywords | product, bile acid catabolism, cytoplasm, disease mutation, intrahepatic cholestasis, lipid metabolism, nadp, oxidoreductase, steroid metabolism |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P51857 |
Total number of polymer chains | 2 |
Total formula weight | 80975.77 |
Authors | Di Costanzo, L.,Drury, J.E.,Penning, T.M.,Christianson, D.W. (deposition date: 2008-07-05, release date: 2008-10-28, Last modification date: 2023-11-01) |
Primary citation | Di Costanzo, L.,Drury, J.E.,Christianson, D.W.,Penning, T.M. Structure and catalytic mechanism of human steroid 5beta-reductase (AKR1D1) Mol.Cell.Endocrinol., 301:191-198, 2009 Cited by PubMed: 18848863DOI: 10.1016/j.mce.2008.09.013 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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