3DL6

Crystal Structure of the A287F/S290G Active Site Mutant of TS-DHFR from Cryptosporidium hominis

3DL6 の概要

• エントリーDOI: 10.2210/pdb3dl6/pdb
• 関連するPDBエントリー: 2OIP 3DL5
• 分子名称: Dihydrofolate reductase, DHFR, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, ... (6 entities in total)
• 機能のキーワード: enzyme active site mutant, enzyme-ligand complex, oxidoreductase
• 由来する生物種: Cryptosporidium hominis
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 311415.37

構造登録者

Martucci, W.E.,Vargo, M.A.,Anderson, K.S. (登録日: 2008-06-26, 公開日: 2008-08-19, 最終更新日: 2023-08-30)

• 主引用文献: Martucci, W.E.,Vargo, M.A.,Anderson, K.S.; Explaining an unusually fast parasitic enzyme: folate tail-binding residues dictate substrate positioning and catalysis in Cryptosporidium hominis thymidylate synthase.; Biochemistry, 47:8902-8911, 2008; PubMed: 18672899; DOI: 10.1021/bi800466z

実験手法

X-RAY DIFFRACTION (3.25 Å)