3DK7
Crystal structure of mutant ABL kinase domain in complex with small molecule fragment
Summary for 3DK7
Entry DOI | 10.2210/pdb3dk7/pdb |
Related | 3DK3 3DK6 |
Descriptor | Proto-oncogene tyrosine-protein kinase ABL1, 2-amino-5-[3-(1-ethyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethylbenzamide, SULFATE ION, ... (4 entities in total) |
Functional Keywords | drug discovery, abl kinase, fragment based, alternative splicing, atp-binding, cell adhesion, chromosomal rearrangement, cytoplasm, cytoskeleton, kinase, lipoprotein, magnesium, manganese, metal-binding, myristate, nucleotide-binding, nucleus, phosphoprotein, proto-oncogene, sh2 domain, sh3 domain, transferase |
Biological source | Mus musculus (mouse) |
Cellular location | Cytoplasm, cytoskeleton: P00520 |
Total number of polymer chains | 2 |
Total formula weight | 64966.00 |
Authors | Lewis, H.A. (deposition date: 2008-06-24, release date: 2008-07-29, Last modification date: 2021-10-20) |
Primary citation | Bounaud, P.-Y.,Gosberg, A.,Hendle, J.,Lewis, H.A.,Romero, R.,Wilson, M.E.,Zhang, F. Crystal structure of mutant ABL kinase domain in complex with small molecule fragment To be Published, |
Experimental method | X-RAY DIFFRACTION (2.01 Å) |
Structure validation
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