3DK3

Crystal structure of mutant ABL kinase domain in complex with small molecule fragment

Summary for 3DK3

• Entry DOI: 10.2210/pdb3dk3/pdb
• Related: 3DK6 3DK7
• Descriptor: Proto-oncogene tyrosine-protein kinase ABL1, 2-amino-5-[3-(1-ethyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethylbenzamide, SULFATE ION, ... (4 entities in total)
• Functional Keywords: drug discovery, abl kinase, fragment based, alternative splicing, atp-binding, cell adhesion, chromosomal rearrangement, cytoplasm, cytoskeleton, kinase, lipoprotein, magnesium, manganese, metal-binding, myristate, nucleotide-binding, nucleus, phosphoprotein, proto-oncogene, sh2 domain, sh3 domain, transferase
• Biological source: Mus musculus (mouse)
• Cellular location: Cytoplasm, cytoskeleton: P00520
• Total number of polymer chains: 2
• Total formula weight: 68718.47

Authors

Lewis, H.A. (deposition date: 2008-06-24, release date: 2008-07-29, Last modification date: 2024-02-21)

• Primary citation: Bounaud, P.-Y.,Gosberg, A.,Hendle, J.,Lewis, H.A.,Romero, R.,Wilson, M.E.,Zhang, F.; Crystal structure of mutant ABL kinase domain in complex with small molecule fragment; To be Published,

Experimental method

X-RAY DIFFRACTION (2.02 Å)