3DK3

Crystal structure of mutant ABL kinase domain in complex with small molecule fragment

3DK3 の概要

• エントリーDOI: 10.2210/pdb3dk3/pdb
• 関連するPDBエントリー: 3DK6 3DK7
• 分子名称: Proto-oncogene tyrosine-protein kinase ABL1, 2-amino-5-[3-(1-ethyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethylbenzamide, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: drug discovery, abl kinase, fragment based, alternative splicing, atp-binding, cell adhesion, chromosomal rearrangement, cytoplasm, cytoskeleton, kinase, lipoprotein, magnesium, manganese, metal-binding, myristate, nucleotide-binding, nucleus, phosphoprotein, proto-oncogene, sh2 domain, sh3 domain, transferase
• 由来する生物種: Mus musculus (mouse)
• 細胞内の位置: Cytoplasm, cytoskeleton: P00520
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 68718.47

構造登録者

Lewis, H.A. (登録日: 2008-06-24, 公開日: 2008-07-29, 最終更新日: 2024-02-21)

• 主引用文献: Bounaud, P.-Y.,Gosberg, A.,Hendle, J.,Lewis, H.A.,Romero, R.,Wilson, M.E.,Zhang, F.; Crystal structure of mutant ABL kinase domain in complex with small molecule fragment; To be Published,

実験手法

X-RAY DIFFRACTION (2.02 Å)