3DJ8

Synthesis of (2S)-2-amino-7,8-epoxyoctanoic acid and structure of its metal-bridging complex with human arginase I

3DJ8 の概要

• エントリーDOI: 10.2210/pdb3dj8/pdb
• 関連するPDBエントリー: 2aeb 2ZAV
• 分子名称: Arginase-1, MANGANESE (II) ION, 6-[(2R)-oxiran-2-yl]-L-norleucine, ... (4 entities in total)
• 機能のキーワード: epoxide binding, manganese cluster, arginine metabolism, disease mutation, hydrolase, manganese, metal-binding, phosphoprotein, urea cycle
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P05089
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 70125.93

構造登録者

Di Costanzo, L.,Christianson, D.W. (登録日: 2008-06-22, 公開日: 2008-07-08, 最終更新日: 2023-11-01)

主引用文献

Zakharian, T.Y.,Di Costanzo, L.,Christianson, D.W.
Synthesis of (2S)-2-amino-7,8-epoxyoctanoic acid and structure of its metal-bridging complex with human arginase I
Org.Biomol.Chem., 6:3240-3243, 2008

PubMed Abstract: The synthesis of (2S)-2-amino-7,8-epoxyoctanoic acid is reported along with the X-ray crystal structure of its complex with human arginase I, revealing unique coordination interactions with two manganese ions in the enzyme active site.

PubMed: 18802628
DOI: 10.1039/b811797g

実験手法

X-RAY DIFFRACTION (1.51 Å)