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3DJ5

Crystal structure of the mouse Aurora-A catalytic domain (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with Compound 290.

Summary for 3DJ5
Entry DOI10.2210/pdb3dj5/pdb
Related2c6d 3d14 3d15 3D2I 3D2K 3DJ6 3DJ7
Descriptorserine/threonine kinase 6, 3-({3-[(6-amino-5-bromopyrimidin-4-yl)sulfanyl]propanoyl}amino)-4-methoxy-N-phenylbenzamide (3 entities in total)
Functional Keywordsaurora a, small-molecule inhibitor, fragment-based drug discovery, kinase, transferase
Biological sourceMus musculus (mouse)
Total number of polymer chains1
Total formula weight32051.56
Authors
Elling, R.A.,Erlanson, D.A.,Yang, W.,Tangonan, B.T.,Hansen, S.K.,Romanowski, M.J. (deposition date: 2008-06-22, release date: 2009-05-05, Last modification date: 2023-08-30)
Primary citationElling, R.A.,A Erlanson, D.,Yang, W.,Tangonan, B.T.,Hansen, S.K.,Romanowski, M.J.
New fragment-based drug discovery
To be Published,
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

222415

數據於2024-07-10公開中

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