3DG1

Segment SSTNVG derived from IAPP

3DG1 の概要

• エントリーDOI: 10.2210/pdb3dg1/pdb
• 関連するPDBエントリー: 1YJO 2OMM
• 分子名称: SSTNVG from Islet Amyloid Polypeptide (2 entities in total)
• 機能のキーワード: steric zipper, iapp, sstnvg, amyloid, protein fibril
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 563.56

構造登録者

Wiltzius, J.J.,Sievers, S.A.,Sawaya, M.R.,Cascio, D.,Eisenberg, D. (登録日: 2008-06-12, 公開日: 2008-07-01, 最終更新日: 2024-04-03)

主引用文献

Wiltzius, J.J.,Sievers, S.A.,Sawaya, M.R.,Cascio, D.,Popov, D.,Riekel, C.,Eisenberg, D.
Atomic structure of the cross-beta spine of islet amyloid polypeptide (amylin).
Protein Sci., 17:1467-1474, 2008

PubMed Abstract: Human islet amyloid polypeptide (IAPP or amylin) is a 37-residue hormone found as fibrillar deposits in pancreatic extracts of nearly all type II diabetics. Although the cellular toxicity of IAPP has been established, the structure of the fibrillar form found in these deposits is unknown. Here we have crystallized two segments from IAPP, which themselves form amyloid-like fibrils. The atomic structures of these two segments, NNFGAIL and SSTNVG, were determined, and form the basis of a model for the most commonly observed, full-length IAPP polymorph.

PubMed: 18556473
DOI: 10.1110/ps.036509.108

実験手法

X-RAY DIFFRACTION (1.66 Å)