3DDS
Crystal structure of glycogen phosphorylase complexed with an anthranilimide based inhibitor GSK261
3DDS の概要
エントリーDOI | 10.2210/pdb3dds/pdb |
関連するPDBエントリー | 3DD1 3DDW |
分子名称 | Glycogen phosphorylase, liver form, N-acetyl-beta-D-glucopyranosylamine, PHOSPHATE ION, ... (9 entities in total) |
機能のキーワード | gp, glycogen phosphorylase, diabetes, allosteric enzyme, carbohydrate metabolism, disease mutation, glycogen metabolism, glycogen storage disease, glycosyltransferase, nucleotide-binding, phosphoprotein, pyridoxal phosphate, transferase |
由来する生物種 | Homo sapiens |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 197928.98 |
構造登録者 | |
主引用文献 | Thomson, S.A.,Banker, P.,Bickett, D.M.,Boucheron, J.A.,Carter, H.L.,Clancy, D.C.,Cooper, J.P.,Dickerson, S.H.,Garrido, D.M.,Nolte, R.T.,Peat, A.J.,Sheckler, L.R.,Sparks, S.M.,Tavares, F.X.,Wang, L.,Wang, T.Y.,Weiel, J.E. Anthranilimide based glycogen phosphorylase inhibitors for the treatment of type 2 diabetes. Part 3: X-ray crystallographic characterization, core and urea optimization and in vivo efficacy. Bioorg.Med.Chem.Lett., 19:1177-1182, 2009 Cited by PubMed: 19138846DOI: 10.1016/j.bmcl.2008.12.085 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.8 Å) |
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