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3DDS

Crystal structure of glycogen phosphorylase complexed with an anthranilimide based inhibitor GSK261

3DDS の概要
エントリーDOI10.2210/pdb3dds/pdb
関連するPDBエントリー3DD1 3DDW
分子名称Glycogen phosphorylase, liver form, N-acetyl-beta-D-glucopyranosylamine, PHOSPHATE ION, ... (9 entities in total)
機能のキーワードgp, glycogen phosphorylase, diabetes, allosteric enzyme, carbohydrate metabolism, disease mutation, glycogen metabolism, glycogen storage disease, glycosyltransferase, nucleotide-binding, phosphoprotein, pyridoxal phosphate, transferase
由来する生物種Homo sapiens
タンパク質・核酸の鎖数2
化学式量合計197928.98
構造登録者
Nolte, R.T. (登録日: 2008-06-06, 公開日: 2009-01-27, 最終更新日: 2023-08-30)
主引用文献Thomson, S.A.,Banker, P.,Bickett, D.M.,Boucheron, J.A.,Carter, H.L.,Clancy, D.C.,Cooper, J.P.,Dickerson, S.H.,Garrido, D.M.,Nolte, R.T.,Peat, A.J.,Sheckler, L.R.,Sparks, S.M.,Tavares, F.X.,Wang, L.,Wang, T.Y.,Weiel, J.E.
Anthranilimide based glycogen phosphorylase inhibitors for the treatment of type 2 diabetes. Part 3: X-ray crystallographic characterization, core and urea optimization and in vivo efficacy.
Bioorg.Med.Chem.Lett., 19:1177-1182, 2009
Cited by
PubMed: 19138846
DOI: 10.1016/j.bmcl.2008.12.085
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (1.8 Å)
構造検証レポート
Validation report summary of 3dds
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-03-27に公開中

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