3DD3

Crystal Structure of the Glutathione Transferase Pi enzyme in complex with the bifunctional inhibitor, Etharapta

3DD3 の概要

• エントリーDOI: 10.2210/pdb3dd3/pdb
• 分子名称: Glutathione S-transferase P, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, (eta6-benzene)ruthenium, ... (5 entities in total)
• 機能のキーワード: transferase, glutathione, detoxification, etharapta, ruthenium, rapta-c, ethacrynic-acid
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 47939.84

構造登録者

Parker, L.J. (登録日: 2008-06-05, 公開日: 2009-04-21, 最終更新日: 2023-11-01)

主引用文献

Ang, W.H.,Parker, L.J.,De Luca, A.,Juillerat-Jeanneret, L.,Morton, C.J.,Lo Bello, M.,Parker, M.W.,Dyson, P.J.
Rational design of an organometallic glutathione transferase inhibitor
Angew.Chem.Int.Ed.Engl., 48:3854-3857, 2009

PubMed Abstract: Double trouble: A hybrid organic-inorganic (organometallic) inhibitor was designed to target glutathione transferases. The metal center is used to direct protein binding, while the organic moiety acts as the active-site inhibitor (see picture). The mechanism of inhibition was studied using a range of biophysical and biochemical methods.

PubMed: 19396894
DOI: 10.1002/anie.200900185

実験手法

X-RAY DIFFRACTION (2.25 Å)