3DCV
Crystal structure of human Pim1 kinase complexed with 4-(4-hydroxy-3-methyl-phenyl)-6-phenylpyrimidin-2(1H)-one
3DCV の概要
エントリーDOI | 10.2210/pdb3dcv/pdb |
分子名称 | Proto-oncogene serine/threonine-protein kinase Pim-1, 4-(4-hydroxy-3-methylphenyl)-6-phenylpyrimidin-2(5H)-one (3 entities in total) |
機能のキーワード | ser/thr protein kinase, nucleotide-binding, phsphorylation, atp-binding, cancer, oncogene, alternative initiation, cytoplasm, manganese, membrane, metal-binding, nucleus, phosphoprotein, polymorphism, proto-oncogene, serine/threonine-protein kinase, transferase |
由来する生物種 | Homo sapiens |
細胞内の位置 | Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 37875.01 |
構造登録者 | Bellamacina, C.R.,Shafer, C.M.,Lindvall, M.,Gesner, T.G.,Yabannavar, A.,Weiping, J.,Song, L.,Walter, A. (登録日: 2008-06-04, 公開日: 2008-08-19, 最終更新日: 2024-04-03) |
主引用文献 | Shafer, C.M.,Lindvall, M.,Bellamacina, C.,Gesner, T.G.,Yabannavar, A.,Jia, W.,Lin, S.,Walter, A. 4-(1H-indazol-5-yl)-6-phenylpyrimidin-2(1H)-one analogs as potent CDC7 inhibitors. Bioorg.Med.Chem.Lett., 18:4482-4485, 2008 Cited by PubMed: 18672368DOI: 10.1016/j.bmcl.2008.07.061 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.7 Å) |
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