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3DCU

FXR with SRC1 and GSK8062

3DCU の概要
エントリーDOI10.2210/pdb3dcu/pdb
関連するPDBエントリー3DCT
分子名称Bile acid receptor, Nuclear receptor coactivator 1, 6-(4-{[3-(2,6-dichlorophenyl)-5-(1-methylethyl)isoxazol-4-yl]methoxy}phenyl)naphthalene-1-carboxylic acid, ... (4 entities in total)
機能のキーワードfxr, nuclear receptor, gw4064, alpha-helical sandwich, activator, alternative splicing, dna-binding, metal-binding, nucleus, receptor, repressor, transcription regulation, zinc, zinc-finger, acyltransferase, chromosomal rearrangement, phosphoprotein, polymorphism, proto-oncogene, transferase, ubl conjugation, transcription-transcription activator complex, transcription/transcription activator
由来する生物種Homo sapiens (human)
詳細
細胞内の位置Nucleus . Isoform 1: Nucleus . Isoform 2: Nucleus . Isoform 3: Nucleus . Isoform 4: Nucleus : Q96RI1
Nucleus : Q15788
タンパク質・核酸の鎖数2
化学式量合計30692.03
構造登録者
Williams, S.P.,Madauss, K.P. (登録日: 2008-06-04, 公開日: 2008-08-12, 最終更新日: 2023-08-30)
主引用文献Akwabi-Ameyaw, A.,Bass, J.Y.,Caldwell, R.D.,Caravella, J.A.,Chen, L.,Creech, K.L.,Deaton, D.N.,Jones, S.A.,Kaldor, I.,Liu, Y.,Madauss, K.P.,Marr, H.B.,McFadyen, R.B.,Miller, A.B.,III, F.N.,Parks, D.J.,Spearing, P.K.,Todd, D.,Williams, S.P.,Wisely, G.B.
Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064.
Bioorg.Med.Chem.Lett., 18:4339-4343, 2008
Cited by
PubMed: 18621523
DOI: 10.1016/j.bmcl.2008.06.073
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (2.95 Å)
構造検証レポート
Validation report summary of 3dcu
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-03-27に公開中

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