3DC9

Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties

3DC9 の概要

関連するPDBエントリー3D8W 3D9Z 3DBU 3DC3 3DCC 3DAZ
分子名称Carbonic anhydrase 2, ZINC ION (3 entities in total)
機能のキーワードcarbonic anhydrase ii complex, caix mimic inhibitors, acetylation, cytoplasm, disease mutation, lyase, metal-binding, polymorphism, zinc
由来する生物種Homo sapiens (human)
細胞内の位置Cytoplasm P00918
ポリマー鎖数1
分子量合計29384.5
構造登録者
Genis, C.,Sippel, K.H.,Case, N.,Govindasamy, L.,Agbandje-Mckenna, M.,Mckenna, R. (登録日: 2008-06-03, 公開日: 2009-03-03, 最終更新日: 2011-07-13)
主引用文献
Genis, C.,Sippel, K.H.,Case, N.,Cao, W.,Avvaru, B.S.,Tartaglia, L.J.,Govindasamy, L.,Tu, C.,Agbandje-McKenna, M.,Silverman, D.N.,Rosser, C.J.,McKenna, R.
Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties
Biochemistry, 48:1322-1331, 2009
PubMed: 19170619 (主引用文献が同じPDBエントリー)
DOI: 10.1021/bi802035f
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (1.6 Å)
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構造検証レポート

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers704.9%0.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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