3DBA

Crystal structure of the cGMP-bound GAF a domain from the photoreceptor phosphodiesterase 6C

3DBA の概要

• エントリーDOI: 10.2210/pdb3dba/pdb
• 分子名称: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha', GUANOSINE-3',5'-MONOPHOSPHATE, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: 3', 5' cgmp, gaf domain, cyclic nucleotide phosphodiesterase, cgmp, hydrolase, lipoprotein, membrane, prenylation, sensory transduction, vision
• 由来する生物種: Gallus gallus (bantam,chickens)
• 細胞内の位置: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential): P52731
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 42602.76

構造登録者

Martinez, S.E.,Heikaus, C.C.,Klevit, R.E.,Beavo, J.A. (登録日: 2008-05-30, 公開日: 2008-07-01, 最終更新日: 2024-02-21)

• 主引用文献: Martinez, S.E.,Heikaus, C.C.,Klevit, R.E.,Beavo, J.A.; The Structure of the GAF A Domain from Phosphodiesterase 6C Reveals Determinants of cGMP Binding, a Conserved Binding Surface, and a Large cGMP-dependent Conformational Change.; J.Biol.Chem., 283:25913-25919, 2008; PubMed: 18614542; DOI: 10.1074/jbc.M802891200

実験手法

X-RAY DIFFRACTION (2.57 Å)