3DA6

Crystal Structure of human JNK3 complexed with N-(3-methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)naphthalen-1-yl)-1H-benzo[d]imidazol-2-amine

3DA6 の概要

• エントリーDOI: 10.2210/pdb3da6/pdb
• 関連するPDBエントリー: 2B1P
• 分子名称: Mitogen-activated protein kinase 10, N-[3-methyl-4-({3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl}oxy)naphthalen-1-yl]-1H-benzimidazol-2-amine (3 entities in total)
• 機能のキーワード: jnk3, kinase, alternative splicing, atp-binding, chromosomal rearrangement, cytoplasm, epilepsy, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : P53779
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42533.21

構造登録者

Cee, V.J.,Cheng, A.C.,Romero, K.,Bellon, S.,Mohr, C.,Whittington, D.A.,Bready, J.,Caenepeel, S.,Coxon, A.,Deak, H.L.,Hodous, B.L.,Kim, J.L.,Lin, J.,Nguyen, H.,Olivieri, P.R.,Patel, V.F.,Wang, L.,Hughes, P.,Geuns-Meyer, S. (登録日: 2008-05-28, 公開日: 2009-01-06, 最終更新日: 2024-02-21)

• 主引用文献: Cee, V.J.,Cheng, A.C.,Romero, K.,Bellon, S.,Mohr, C.,Whittington, D.A.,Bak, A.,Bready, J.,Caenepeel, S.,Coxon, A.,Deak, H.L.,Fretland, J.,Gu, Y.,Hodous, B.L.,Huang, X.,Kim, J.L.,Lin, J.,Long, A.M.,Nguyen, H.,Olivieri, P.R.,Patel, V.F.,Wang, L.,Zhou, Y.,Hughes, P.,Geuns-Meyer, S.; Pyridyl-pyrimidine benzimidazole derivatives as potent, selective, and orally bioavailable inhibitors of Tie-2 kinase; Bioorg.Med.Chem.Lett., 19:424-427, 2009; PubMed: 19062275; DOI: 10.1016/j.bmcl.2008.11.056

実験手法

X-RAY DIFFRACTION (2 Å)