3D9V

CRYSTAL STRUCTURE OF ROCK I BOUND TO H-1152P A DI-METHYLATED VARIANT OF FASUDIL

「2ETO」から置き換えられました

3D9V の概要

• エントリーDOI: 10.2210/pdb3d9v/pdb
• 分子名称: Rho-associated protein kinase 1, (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE (2 entities in total)
• 機能のキーワード: dimer, dimerization, kinase, phosphorylation, fasudil, apoptosis, atp-binding, coiled coil, cytoplasm, golgi apparatus, membrane, metal-binding, nucleotide-binding, phorbol-ester binding, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase, zinc, zinc-finger
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: Q13464
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 96663.41

構造登録者

Jacobs, M. (登録日: 2008-05-27, 公開日: 2008-06-10, 最終更新日: 2024-02-21)

• 主引用文献: Jacobs, M.,Hayakawa, K.,Swenson, L.,Bellon, S.,Fleming, M.,Taslimi, P.,Doran, J.; The structure of dimeric ROCK I reveals the mechanism for ligand selectivity.; J.Biol.Chem., 281:260-268, 2006; PubMed: 16249185; DOI: 10.1074/jbc.M508847200

実験手法

X-RAY DIFFRACTION (3.3 Å)