3D9C

Crystal Structure PTP1B complex with aryl Seleninic acid

3D9C の概要

• エントリーDOI: 10.2210/pdb3d9c/pdb
• 分子名称: Tyrosine-protein phosphatase non-receptor type 1, (4-{(2S)-2-[(tert-butoxycarbonyl)amino]-3-methoxy-3-oxopropyl}phenyl)methaneseleninic acid (3 entities in total)
• 機能のキーワード: inhibitor, covalent bond, acetylation, endoplasmic reticulum, hydrolase, membrane, oxidation, phosphoprotein, polymorphism, protein phosphatase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37769.95

構造登録者

Abdo, M.,Liu, S.,Zhou, B.,Walls, C.D.,Knapp, S.,Zhang, Z.-Y. (登録日: 2008-05-27, 公開日: 2008-09-23, 最終更新日: 2024-02-21)

• 主引用文献: Abdo, M.,Liu, S.,Zhou, B.,Walls, C.D.,Wu, L.,Knapp, S.,Zhang, Z.Y.; Seleninate in place of phosphate: irreversible inhibition of protein tyrosine phosphatases.; J.Am.Chem.Soc., 130:13196-13197, 2008; PubMed: 18781746; DOI: 10.1021/ja804489m

実験手法

X-RAY DIFFRACTION (2.3 Å)