3D8C

Factor inhibiting HIF-1 alpha D201G mutant in complex with ZN(II), alpha-ketoglutarate and HIF-1 alpha 19mer

Summary for 3D8C

• Entry DOI: 10.2210/pdb3d8c/pdb
• Related: 1H2K 1H2L 1H2M 1H2N 1YCI 2ILM
• Descriptor: Hypoxia-inducible factor 1 alpha inhibitor, HYPOXIA-INDUCIBLE FACTOR 1 ALPHA, ZINC ION, ... (7 entities in total)
• Functional Keywords: fih, hif, dsbh, oxygenase, transcription, hypoxia, inhibitor 2-oxoglutarate, asparaginyl hydroxylase, transcription regulator, oxidoreductase, dioxygenase, iron, metal-binding, nucleus, transcription regulation
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus (Potential): Q9NWT6
• Total number of polymer chains: 2
• Total formula weight: 42817.16

Authors

McDonough, M.A.,Chowdhury, R.,Schofield, C.J. (deposition date: 2008-05-23, release date: 2008-08-12, Last modification date: 2023-08-30)

• Primary citation: Hewitson, K.S.,Holmes, S.L.,Ehrismann, D.,Hardy, A.P.,Chowdhury, R.,Schofield, C.J.,McDonough, M.A.; Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH).; J.Biol.Chem., 283:25971-25978, 2008; PubMed: 18611856; DOI: 10.1074/jbc.M804999200

Experimental method

X-RAY DIFFRACTION (2.1 Å)