3D8C

Factor inhibiting HIF-1 alpha D201G mutant in complex with ZN(II), alpha-ketoglutarate and HIF-1 alpha 19mer

Summary for 3D8C

Related2ILM 1H2K 1H2L 1H2M 1H2N 1YCI
DescriptorHypoxia-inducible factor 1 alpha inhibitor, HYPOXIA-INDUCIBLE FACTOR 1 ALPHA, ZINC ION, ... (7 entities in total)
Functional Keywordsfih, hif, dsbh, oxygenase, transcription, hypoxia, inhibitor 2-oxoglutarate, asparaginyl hydroxylase, transcription regulator, oxidoreductase, dioxygenase, iron, metal-binding, nucleus, transcription regulation
Biological sourceHomo sapiens (human)
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Cellular locationNucleus (Potential) Q9NWT6
Total number of polymer chains2
Total molecular weight42817.16
Authors
McDonough, M.A.,Chowdhury, R.,Schofield, C.J. (deposition date: 2008-05-23, release date: 2008-08-12, Last modification date: 2011-07-13)
Primary citation
Hewitson, K.S.,Holmes, S.L.,Ehrismann, D.,Hardy, A.P.,Chowdhury, R.,Schofield, C.J.,McDonough, M.A.
Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH).
J.Biol.Chem., 283:25971-25978, 2008
PubMed: 18611856 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M804999200
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.1 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.252703.1%5.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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