3D8C

Factor inhibiting HIF-1 alpha D201G mutant in complex with ZN(II), alpha-ketoglutarate and HIF-1 alpha 19mer

3D8C の概要

• エントリーDOI: 10.2210/pdb3d8c/pdb
• 関連するPDBエントリー: 1H2K 1H2L 1H2M 1H2N 1YCI 2ILM
• 分子名称: Hypoxia-inducible factor 1 alpha inhibitor, HYPOXIA-INDUCIBLE FACTOR 1 ALPHA, ZINC ION, ... (7 entities in total)
• 機能のキーワード: fih, hif, dsbh, oxygenase, transcription, hypoxia, inhibitor 2-oxoglutarate, asparaginyl hydroxylase, transcription regulator, oxidoreductase, dioxygenase, iron, metal-binding, nucleus, transcription regulation
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus (Potential): Q9NWT6
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 42817.16

構造登録者

McDonough, M.A.,Chowdhury, R.,Schofield, C.J. (登録日: 2008-05-23, 公開日: 2008-08-12, 最終更新日: 2023-08-30)

• 主引用文献: Hewitson, K.S.,Holmes, S.L.,Ehrismann, D.,Hardy, A.P.,Chowdhury, R.,Schofield, C.J.,McDonough, M.A.; Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH).; J.Biol.Chem., 283:25971-25978, 2008; PubMed: 18611856; DOI: 10.1074/jbc.M804999200

実験手法