3D7Z

Crystal Structure of P38 Kinase in Complex with a biphenyl amide inhibitor

3D7Z の概要

• エントリーDOI: 10.2210/pdb3d7z/pdb
• 関連するPDBエントリー: 2ZB0 2ZB1 3D83
• 分子名称: Mitogen-activated protein kinase 14, SULFATE ION, N~3~-cyclopropyl-N~4~'-(cyclopropylmethyl)-6-methylbiphenyl-3,4'-dicarboxamide, ... (5 entities in total)
• 機能のキーワード: p38, serine/threonine protein kinase, map kinase, atp-binding, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : Q16539
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41895.79

構造登録者

Somers, D.O.,Patel, S. (登録日: 2008-05-22, 公開日: 2008-07-22, 最終更新日: 2023-11-15)

• 主引用文献: Angell, R.,Aston, N.M.,Bamborough, P.,Buckton, J.B.,Cockerill, S.,deBoeck, S.J.,Edwards, C.D.,Holmes, D.S.,Jones, K.L.,Laine, D.I.,Patel, S.,Smee, P.A.,Smith, K.J.,Somers, D.O.,Walker, A.L.; Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity.; Bioorg.Med.Chem.Lett., 18:4428-4432, 2008; PubMed: 18614366; DOI: 10.1016/j.bmcl.2008.06.048

実験手法

X-RAY DIFFRACTION (2.1 Å)