3D7Z

Crystal Structure of P38 Kinase in Complex with a biphenyl amide inhibitor

3D7Z の概要

• エントリーDOI: 10.2210/pdb3d7z/pdb
• 関連するPDBエントリー: 2ZB0 2ZB1 3D83
• 分子名称: Mitogen-activated protein kinase 14, SULFATE ION, N~3~-cyclopropyl-N~4~'-(cyclopropylmethyl)-6-methylbiphenyl-3,4'-dicarboxamide, ... (5 entities in total)
• 機能のキーワード: p38, serine/threonine protein kinase, map kinase, atp-binding, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : Q16539
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41895.79

構造登録者

Somers, D.O.,Patel, S. (登録日: 2008-05-22, 公開日: 2008-07-22, 最終更新日: 2023-11-15)

主引用文献

Angell, R.,Aston, N.M.,Bamborough, P.,Buckton, J.B.,Cockerill, S.,deBoeck, S.J.,Edwards, C.D.,Holmes, D.S.,Jones, K.L.,Laine, D.I.,Patel, S.,Smee, P.A.,Smith, K.J.,Somers, D.O.,Walker, A.L.
Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity.
Bioorg.Med.Chem.Lett., 18:4428-4432, 2008

PubMed Abstract: The biphenyl amides (BPAs) are a novel series of p38alpha MAP kinase inhibitor. The optimisation of the series to give compounds that are potent in an in vivo disease model is discussed. SAR is presented and rationalised with reference to the crystallographic binding mode.

PubMed: 18614366
DOI: 10.1016/j.bmcl.2008.06.048

実験手法

X-RAY DIFFRACTION (2.1 Å)